Publications
ALL PUBLICATIONS: PUBMED2026
A Modular Platform for Purification of Organelle-associated Mitochondria Reveals Functional Specialization at Organelle Contact Sites
George Maxwell Otto, Akimi Green, Jennifer Cabarrus, Francisco Javier Miralles, Parker Torres, Lorenzo DeLeon, Jane Chea, Daphnee M Marciniak, Claude Beltejar, Young V Kwon, Shao-En Ong, David M Shechner, Yasemin Sancak. bioRxiv. DOI
ER-localized ceramide accumulation contributes to replicative senescence.
Shweta Chitkara, Mengru Li, Natasha Gozali, Andrey Kuzmin, Artem Pliss, Paras Prasad, Yasemin Sancak, G Ekin Atilla-Gokcumen. Cell Chem Biol. PubMed · DOI
Periprocedural therapeutics do not impair extracellular mitochondrial viability in transplantation.
Francisco Javier Miralles, Keiko Lynne Prijoles, Ashtyn Winter, Michael R Levitt, Yasemin Sancak, Melanie Walker. J Cereb Blood Flow Metab. PubMed · DOI
Autologous mitochondrial transplant for acute cerebral ischemia: Phase 1 trial results and review.
Melanie Walker, Michael R Levitt, Emma M Federico, Francisco Javier Miralles, Sam Hs Levy, Keiko Lynne Prijoles, Ashtyn Winter, Jennifer K Swicord, Yasemin Sancak. J Cereb Blood Flow Metab. PubMed · DOI
2025
Mitochondria transfer.
Navdeep S Chandel, Marni J Falk, Janine H Santos, Jonathan R Brestoff, Ana V Lechuga-Vieco, Yasemin S Sancak, Quan Chen, Alvaro A Elorza, Rubén Quintana-Cabrera. Nat Metab. PubMed · DOI
Radiolabeling isolated mitochondria with Tc-99m: A first-in-field protocol and early feasibility findings.
Melanie Walker, Francisco Javier Miralles, Keiko Prijoles, Jacob S Kazmi, Jennifer Hough, David Lewis, Michael R Levitt, Yasemin Sancak. Biol Methods Protoc. PubMed · DOI
Mitochondrial calcium signaling regulates branched-chain amino acid catabolism in fibrolamellar carcinoma.
Nicole M Marsh, Melissa J S MacEwen, Jane Chea, Heidi L Kenerson, Albert A Kwong, Timothy M Locke, Francisco Javier Miralles, Tanmay Sapre, Natasha Gozali, Madeleine L Hart, Theo K Bammler, James W MacDonald, Lucas B Sullivan, G Ekin Atilla-Gokcumen, Shao-En Ong, John D Scott, Raymond S Yeung, Yasemin Sancak. Sci Adv. PubMed · DOI
Mechanism of MCUB-Dependent Inhibition of Mitochondrial Calcium Uptake.
Neeraj K Rai, David R Eberhardt, Anthony M Balynas, Melissa J S MacEwen, Ashley R Bratt, Yasemin Sancak, Dipayan Chaudhuri. J Cell Physiol. PubMed · DOI
TMEM65 joins the mitochondrial Ca2+ club.
Yasemin Sancak. Nat Metab. PubMed · DOI
Synchronized long-read genome, methylome, epigenome and transcriptome profiling resolve a Mendelian condition.
Mitchell R Vollger, Jonas Korlach, Kiara C Eldred, Elliott Swanson, Jason G Underwood, Stephanie C Bohaczuk, Yizi Mao, Yong-Han H Cheng, Jane Ranchalis, Elizabeth E Blue, Ulrike Schwarze, Katherine M Munson, Christopher T Saunders, Aaron M Wenger, Aimee Allworth, Sirisak Chanprasert, Brittney L Duerden, Ian Glass, Martha Horike-Pyne, Michelle Kim, Kathleen A Leppig, Ian J McLaughlin, Jessica Ogawa, Elisabeth A Rosenthal, Sam Sheppeard, Stephanie M Sherman, Samuel Strohbehn, Amy L Yuen, Andrew W Stacey, University of Washington Center for Rare Disease Research, Undiagnosed Diseases Network, Thomas A Reh, Peter H Byers, Michael J Bamshad, Fuki M Hisama, Gail P Jarvik, Yasemin Sancak, Katrina M Dipple, Andrew B Stergachis. Nat Genet. PubMed · DOI
2024
High-throughput identification of calcium-regulated proteins across diverse proteomes.
Timothy M Locke, Rose Fields, Hayden Gizinski, George M Otto, Melissa J S MacEwen, Domnita-Valeria Rusnac, Peixian He, David M Shechner, Chris D McGann, Matthew D Berg, Judit Villen, Yasemin Sancak, Devin K Schweppe. Cell Rep. PubMed · DOI
Cytosolic calcium regulates hepatic mitochondrial oxidation, intrahepatic lipolysis, and gluconeogenesis via CAMKII activation.
Traci E LaMoia, Brandon T Hubbard, Mateus T Guerra, Ali Nasiri, Ikki Sakuma, Mario Kahn, Dongyan Zhang, Russell P Goodman, Michael H Nathanson, Yasemin Sancak, Mark Perelis, Vamsi K Mootha, Gerald I Shulman. Cell Metab. PubMed · DOI
The microtubule targeting agent ST-401 triggers cell death in interphase and prevents the formation of polyploid giant cancer cells.
Juan Jesus Vicente, Kainat Khan, Grant Tillinghast, José L McFaline-Figueroa, Yasemin Sancak, Nephi Stella. J Transl Med. PubMed · DOI
Acylation of MLKL Impacts Its Function in Necroptosis.
Apoorva J Pradhan, Shweta Chitkara, Ricardo X Ramirez, Viviana Monje-Galvan, Yasemin Sancak, G Ekin Atilla-Gokcumen. ACS Chem Biol. PubMed · DOI
2023
Role of mitochondria in the myopathy of juvenile dermatomyositis and implications for skeletal muscle calcinosis.
Bhargavi Duvvuri, Lauren M Pachman, Payton Hermanson, Ting Wang, Richard Moore, Dennis Ding-Hwa Wang, Aaron Long, Gabrielle A Morgan, Stephen Doty, Rong Tian, Yasemin Sancak, Christian Lood. J Autoimmun. PubMed · DOI
Mathematical modeling and biochemical analysis support partially ordered calmodulin-myosin light chain kinase binding.
Melissa J S MacEwen, Domnita-Valeria Rusnac, Henok Ermias, Timothy M Locke, Hayden E Gizinski, Joseph P Dexter, Yasemin Sancak. iScience. PubMed · DOI
Beyond the matrix: structural and physiological advancements in mitochondrial calcium signaling.
Melissa J S MacEwen, Yasemin Sancak. Biochem Soc Trans. PubMed · DOI
2022
Mitochondrial calcium uniporter stabilization preserves energetic homeostasis during Complex I impairment.
Enrique Balderas, David R Eberhardt, Sandra Lee, John M Pleinis, Salah Sommakia, Anthony M Balynas, Xue Yin, Mitchell C Parker, Colin T Maguire, Scott Cho, Marta W Szulik, Anna Bakhtina, Ryan D Bia, Marisa W Friederich, Timothy M Locke, Johan L K Van Hove, Stavros G Drakos, Yasemin Sancak, Martin Tristani-Firouzi, Sarah Franklin, Aylin R Rodan, Dipayan Chaudhuri. Nat Commun. PubMed · DOI
2021
Mitochondrial clearance of calcium facilitated by MICU2 controls insulin secretion.
N Vishnu, A Hamilton, A Bagge, A Wernersson, E Cowan, H Barnard, Y Sancak, K J Kamer, P Spégel, M Fex, A Tengholm, V K Mootha, D G Nicholls, H Mulder. Mol Metab. PubMed · DOI
2020
Evolutionary divergence reveals the molecular basis of EMRE dependence of the human MCU.
Melissa Js MacEwen, Andrew L Markhard, Mert Bozbeyoglu, Forrest Bradford, Olga Goldberger, Vamsi K Mootha, Yasemin Sancak. Life Sci Alliance. PubMed · DOI
A-kinase-anchoring protein 1 (dAKAP1)-based signaling complexes coordinate local protein synthesis at the mitochondrial surface.
Laura Gabrovsek, Kerrie B Collins, Stacey Aggarwal, Lauren M Saunders, Ho-Tak Lau, Danny Suh, Yasemin Sancak, Cole Trapnell, Shao-En Ong, F Donelson Smith, John D Scott. J Biol Chem. PubMed · DOI
2019
Exploring the In Vivo Role of the Mitochondrial Calcium Uniporter in Brown Fat Bioenergetics.
Daniel Flicker, Yasemin Sancak, Eran Mick, Olga Goldberger, Vamsi K Mootha. Cell Rep. PubMed · DOI
The role of metabolism in cellular processes.
Kivanc Birsoy, Yasemin Sancak. Mol Biol Cell. PubMed · DOI
2018
MICU1 imparts the mitochondrial uniporter with the ability to discriminate between Ca2+ and Mn2+.
Kimberli J Kamer, Yasemin Sancak, Yevgenia Fomina, Joshua D Meisel, Dipayan Chaudhuri, Zenon Grabarek, Vamsi K Mootha. Proc Natl Acad Sci U S A. PubMed · DOI
A Protective Role for Triacylglycerols during Apoptosis.
Nasi Li, Yasemin Sancak, Jonna Frasor, G Ekin Atilla-Gokcumen. Biochemistry. PubMed · DOI
2017
Cardiovascular homeostasis dependence on MICU2, a regulatory subunit of the mitochondrial calcium uniporter.
Alexander G Bick, Hiroko Wakimoto, Kimberli J Kamer, Yasemin Sancak, Olga Goldberger, Anna Axelsson, Daniel M DeLaughter, Joshua M Gorham, Vamsi K Mootha, J G Seidman, Christine E Seidman. Proc Natl Acad Sci U S A. PubMed · DOI